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Titlebook: Cyclic Nucleotides in the Nervous System; John Daly Book 1977 Plenum Press, New York 1977 adenosine.biology.brain.communication.experiment

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书目名称Cyclic Nucleotides in the Nervous System
编辑John Daly
视频video
图书封面Titlebook: Cyclic Nucleotides in the Nervous System;  John Daly Book 1977 Plenum Press, New York 1977 adenosine.biology.brain.communication.experiment
描述The elucidation of the cellular and molecular bases underlying the inte­ grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib­ ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo­ tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera­ ture of
出版日期Book 1977
关键词adenosine; biology; brain; communication; experiment; health; nervous system; neurons; physiology; research; s
版次1
doihttps://doi.org/10.1007/978-1-4613-4127-7
isbn_softcover978-1-4613-4129-1
isbn_ebook978-1-4613-4127-7
copyrightPlenum Press, New York 1977
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Enzymatic Formation, Degradation, and Action of Cyclic Nucleotides, membrane, with its activity regulated by a receptor(s) exposed to extracellular space (cf. review by Perkins, 1973). Receptors include those for the following hormones: catecholamines, histamine, serotonin, and polypeptides. In addition, the activity of adenylate cyclase is dependent on a variety o
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Accumulation of Cyclic Nucleotides,tors, magnesium, manganese, and calcium ions, and levels of ATP and GTP and, in addition, the existence of multiple enzyme forms with differing properties even within one cell make it difficult or impossible to extrapolate results obtained with homogenates to the functional operation of cyclic nucle
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Conclusion,us system. The present, already voluminous literature provides many indications of important roles for cyclic AMP in (1) establishment of the synaptically integrated central nervous system, (2) inhibitory regulation of membrane properties and hence of neuronal activity and responsiveness, (3) contro
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Sarah Hamel,Abdesselem Boulkrounenosine, and other compounds: (3) the levels and properties of cyclic nucleotide phosphodiesterases; and (4) the levels of cyclic AMP-dependent protein kinases with binding sites that presumably sequester cyclic AMP. The subcellular distribution and availability of ions such as calcium and magnesium
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